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Dr. Alejandro Hernández

E-mail:

alejandro.hernandez@usach.cl

Biografía:

Cirujano Dentista, Universidad de Chile, Chile, 1969. Licenciado en Ciencias Odontológicas, Universidad de Chile, 1969. Postdoctoral Fellow, Neurobiology and Anesthesiology Branch, NIDR-National Institutes of Health (NIH), Bethesda, MD, USA, 1983-1984.

Lineas de Investigación:

Bases neurobiológicas experimentales y teóricas del aprendizaje y la plasticidad sináptica: malnutrición y programación fetal, adicción alimentaria

Fisiología sensorial: dolor crónico.

Proyectos:

-Efectos farmacológicos del entactógeno Éxtasis en la conducta de ayuda en ratas: aspectos pro-sociales y neuroplásticos. Dicyt, 2020-2023. Co-investigador

-The pannexin 1 channel: a missed link in neuroplasticity of the prefrontal cortical-accumbens pathway? A possible role in dietary addiction Dicyt, 2019-2022. Investigador Responsable

-Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the initiating mechanism of chronic pain. Fondecyt, 2018-2021. Co-investigador

-Hybrid cathinones, oxazolines and benzofuranes as tools for modulating MDMA (3,4-methylenedioxymethamphe-tamine)-like effects in rats. Dicyt. 2017-2019. Co-investigador

-Does high-fat diet alter synaptic plasticity in the prefrontal cortical-accumbens pathway? Neural basis of dietary addiction Dicyt. 2016-2018. Investigador Responsable

-Pharmacological characterization of Ecstasy derivatives as tools for the modulation of entactogenic-like effects in rats DICYT 021401SB. Co-investigador. Dicyt. 2014-2016 Co-investigador.

-Influence of brain-derived neurotrophic factor (BDNF) on 5-HT2A receptor functionality: consequences on SSRI efficacy in experimental neuropathic pain. Dicyt. 2012-2014 Investigador Responsible.

-Role of spinal cord LTP in the triggering and maintenance of chronic pain: A long-lasting study in the rat Fondecyt 2012-2015 Co-investigador.

Últimas Publicaciones:

-Lobos N, Lux S, Zepeda RJ, Pelissier T, Marcos JL, Bustos-Quevedo G, Hernández A, Constandil L. 2023 Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice International Journal of Molecular Sciences, 1661-6596. doi: 10.3390/ijms24098359

-Sáez-Briones P, Palma B, Burgos H, Barra R, Hernández A., 2023, Aromatic Bromination Abolishes Deficits in Visuospatial Learning Induced by MDMA ("Ecstasy") in Rats While Preserving the Ability to Increase LTP in the Prefrontal Cortex International Journal of Molecular Sciences. 1661-6596 doi: 10.3390/ijms24043724

-Cayupe B, Troncoso B, Morgan C, Sáez-Briones P, Sotomayor-Zárate R, Constandil L, Hernández A, Morselli E, Barra R. No 2022 The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition International Journal of Molecular Sciences , 1661-6596 doi: 10.3390/ijms231911965

-Morgan C, Sáez-Briones P, Barra R, Reyes A, Zepeda-Morales K, Constandil L, Ríos M, Ramírez P, Burgos H, Hernández A. 2022, Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity International Journal of Molecular Sciences, 1661-6596. doi: 10.3390/ijms231710089

-Bravo D, Zepeda-Morales K, Maturana CJ, Retamal JS, Hernández A, Pelissier T, Barra R, Sáez-Briones P, Burgos H, Constandil L., 2022, NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats International Journal of Molecular Sciences 1661-6596, doi: 10.3390/ijms23126705

-Cayupe B, Morgan C, Puentes G, Valladares L, Burgos H, Castillo A, Hernández A, Constandil L, Ríos M, Sáez-Briones P, Barra R., 2021 Hypertension in Prenatally Undernourished Young-Adult Rats Is Maintained by Tonic Reciprocal Paraventricular-Coerulear Excitatory Interactions. Molecules, 1420-3049. doi: 10.3390/molecules26123568

-González V, Pelissier T, Cazanga V, Hernández A, Constandil L., 2020, Magnesium salt, a simple strategy to improve methadone analgesia in chronic pain: An isobolographic preclinical study in neuropathic mice Frontiers in Pharmacology, 1663-9812, doi: 10.3389/fphar.2020.00566

-Barra R, Morgan C, Sáez-Briones P, Reyes-Parada M, Burgos H, Morales B, Hernández A., 2019, Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition Nutrition Reviews 0029-6643 doi: 10.1093/nutrit/nuy047

-Sáez-Briones P, Castro-Castillo V, Díaz-Véliz G, Valladares L, Barra R, Hernández A, Cassels BK., 2019 Aromatic bromination abolishes the psychomotor features and pro-social responses of MDMA ("Ecstasy") in rats and preserves affinity for the serotonin transporter (SERT), Frontiers in Pharmacology, 1663-9812. doi: 10.3389/fphar.2019.00157

-Burgos H, Hernández A, Constandil L, Ríos M, Flores O, Puentes G, Hernández K, Morgan C, Valladares L, Castillo A, Cofre C, Milla LA, Sáez-Briones P, Barra R., 2019, Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats Behavioural Brain Research, 0166-4328, doi: 10.1016/j.bbr.2019.02.001

-Lux S, Lobos N, Lespay-Rebolledo C, Salas-Huenuleo E, Kogan MJ, Flores C, Pinto M, Hernández A, Pelissier T, Constandil L., 2019, The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat Journal of Pharmacy and Pharmacology, 0022-3573 doi: 10.1111/jphp.13064