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Dr. Elías Leiva

Cargo:

Director

E-mail:

elias.leiva@usach.cl

Biografía:

Doctor en Ciencias Biomédicas, Neurociencias, Universidad de Chile, 2009, Chile

Lineas de Investigación:

Excitabilidad cortical, Integración sináptica, mecanismos oscilatorios, enfermedades neuropsiquiátricas

Proyectos:

"Role of the UP and DOWN excitability states of VIP and SST interneurons in the dynamic frequency change between cortical layers of the medial prefrontal cortex". FONDECYT 1220680. 2022-2026. Investigador responsable

Control of oscillatory switching in prefrontal cortex MISTI MIT. 2019-2022. Co-investigador

Cholinergic modulation of dendritic excitability and synaptic integration in medial prefrontal cortex layer 2/3 through CAN and H channels. FONDECYT 1181814. 2018-2021. Investigador responsable

Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the mechanisms of chronic pain FONDECYT 1181622. 2018-2022 Co-investigador

Role of trpm4 channel in the regulation of firing patterns and excitability of the prefrontal cortex neurons FONDECYT 11140731. 2014-2017 Investigador responsable

Fortalecimiento de la docencia en Bioquímica Clínica, Genética y postgrado de la Facultad de Química y Biología ANID. 2014-2017 Investigador responsable

Últimas Publicaciones:

-Marileo AM, Gavilán J, San Martín VP, Lara CO, Sazo A, Muñoz-Montesino C, Castro PA, Burgos CF, Leiva-Salcedo E, Aguayo LG, Moraga-Cid G, Fuentealba J, Yévenes GE., 2023, Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine. Frontiers in Molecular Neuroscience 1662-5099 doi: 10.3389/fnmol.2022.1083189

-Acuña-Castillo C, Vidal M, Inostroza-Molina A, Vallejos-Vidal E, Luraschi R, Figueroa M, Barrera-Avalos C, Vera R, Vargas S, Valdes D, Maisey K, Imarai M, Leiva-Salcedo E, Escobar A, Reyes-Cerpa S, Gaete A, Palma-Vejares R, Travisany D, Rojo LE, Reyes-López FE, Sandino AM., 2022 Comparison of the First and Second Wave of Infections by SARS-CoV-2: A Retrospective and Longitudinal Study from a Primary Health Care Center in Santiago of Chile Frontiers in public health, 2296-2565. doi: 10.3389/fpubh.2022.913519

-Acuña-Castillo C, Vidal M, Inostroza-Molina A, Vallejos-Vidal E, Luraschi R, Figueroa M, Barrera-Avalos C, Vera R, Vargas S, Valdes D, Maisey K, Imarai M, Leiva-Salcedo E, Escobar A, Reyes-Cerpa S, Gaete A, Palma-Vejares R, Travisany D, Rojo LE, Reyes-López FE, Sandino AM., 2022 First Identification of Reinfection by a Genetically Different Variant of SARS-CoV-2 in a Homeless Person from the Metropolitan Area of Santiago, Chile. Journal of Environmental and Public Health, 1687-9805, doi: 10.1155/2022/3859071

-Alejandro Escobar, Felipe E Reyes-López, Mónica L Acevedo, Luis Alonso-Palomares, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Hugo Portillo, Jimena Gatica, Ivan Flores, Estefanía Nova-Lamperti, Carlos Barrera-Avalos, María Rosa Bono, Leonardo Vargas, Valeska Simon, Elias Leiva-Salcedo, Cecilia Vial, Juan Hormazabal 8, Lina Jimena Cortes, Daniel Valdés, Ana M Sandino, Mónica Imarai, Claudio Acuña-Castillo, 2022, Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group Frontier in immunology, 1664-3224 doi: 10.3389/fimmu.2021.766278

-Carlos Barrera-Avalos , Pedro Briceño, Daniel Valdés, Mónica Imarai, Elías Leiva-Salcedo, Leonel E Rojo, Luis A Milla, Juan Pablo Huidobro-Toro, Claudia Robles-Planells, Alejandro Escobar, Francesco Di Virgilio, Gabriel Morón, Daniela Sauma, Claudio Acuña-Castillo, 2021, P2X7 receptor is essential for cross-dressing of bone marrow-derived dendritic cells. iScience , 2589-0042 doi: 10.1016/j.isci.2021.103520

-Riquelme D, Peralta FA, Navarro FD, Moreno C, Leiva-Salcedo E., 2021, ICAN (TRPM4) Contributes to the Intrinsic Excitability of Prefrontal Cortex Layer 2/3 Pyramidal Neurons, International Journal of Molecular Science, 1422-0067, doi: 10.3390/ijms22105268

-Denise Riquelme, Oscar Cerda, Elias Leiva-Salcedo, 2021, TRPM4 Expression During Postnatal Developmental of Mouse CA1 Pyramidal Neurons Frontiers in Neuroanatomy,1662-5129 doi.org/10.3389/fnana.2021.643287

-Barrera-Avalos, Carlos; Diaz, Ximena; Madrid, Bastian; Michelson, Sofia A.; Robles-Planells, Claudia; Sanchez-Guerrero, Giselle; Ahumada, Viviana; Mella-Torres, Andrea; Rojo, Leonel E.; Imarai, Monica; Milla, Luis A.; Leiva-Salcedo, Elias; Murgas, Paola; Fernandez, Ricardo; Escobar, Alejandro; Acuna-Castillo, Claudio, 2021, In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells Biomed Research International, 2314-6133. doi: 10.1155/2021/6626851

-Barrera-Avalos, Carlos; Mena, Javier; Lopez, Ximena; Cappelli, Claudio; Neira, Tanya; Imarai, Monica; Fernandez, Ricardo; Robles-Planells, Claudia; Rojo, Leonel E.; Milla, Luis A.; Leiva-Salcedo, Elias; Escobar, Alejandro; Acuna-Castillo, Claudio, 2021 Adenosine triphosphate, polymyxin B and B16 cell-derived immunization induce anticancer response Immunotherapy, 1750-7448. doi: 10.2217/imt-2020-0209

-Canales J, Cruz P, Díaz N, Riquelme D, Leiva-Salcedo E, Cerda O., 2020, K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity. ICells, 2073-4409. doi: 10.3390/cells9102273

-Robles-Planells C, Michelson SA, Mena J, Escrig D, Rojas JL, Sanchez-Guerrero G, Hernández R, Barrera-Avalos C, Rojo LE, Sauma D, Kalergis AM, Imarai M, Fernández R, Robles CA, Leiva-Salcedo E, Santander R, Escobar A, Acuña-Castillo C., 2019 Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma. Frontiers in pharmacology., 1663-9812. doi: 10.3389/fphar.2019.01201

-Blanco C, Morales D, Mogollones I, Vergara-Jaque A, Vargas C, Álvarez A, Riquelme D, Leiva-Salcedo E, González W, Morales D, Maureira D, Aldunate I, Cáceres M, Varela D, Cerda O., 2019 EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion. FASEB J. 1530-6860. doi: 10.1096/fj.201900136R.