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Dr. Fernando Ortíz
Doctor en Ciencias Fisiológicas, Fisiología y Neurociencia, PUC, 2011, Chile
Desmielinización, Neuroinflamación, interacción glia-glia, interacción glia-neurona.
-"Astrocytic cytokine signaling in multiple sclerosis: implications in disease progression "Fondecyt regular, ANID 2021- 4 años. Investigador responsable
-"Vagal nerve stimulation: a new approach to treat MS" , "VRIP UAutonoma" 2021, 2 años, Co-investigador
"Multi-Target Drug Design Against Neurodegenerative Diseases" "REDES CONICYT PCI" 2020, 2 años Co-Investigador
-"Central Role Of Astrocytes In Neuronal-Driven Remyelination". ECOS-Sud CONICYT PCI 2019 3 años Investigador responsable
-"Role of reactive astrocytes at the different stages of remyelination in an in vivo modelof multiple sclerosis" "NeurATRIS - ANR (Union Europea)" 2018 3 años Investigador responsable
-"Effect of astrocyte photoactivation on oligodendrocyte differentiation in demyelinated lesions"VRIP UAutonoma. 2018, 2 años Co-investigador
-"Role of astrocytes in the remyelination of the corpus callosum in a model of MS lesions." Fondecyt iniciacion, ANID 2017. 3 años. Investigador responsable
-"Role Of Astrocytes In The Remyelination Of The Corpus Callosum In A Model Of Ms Lesions." "French Multiple Sclerosis Research Society (ARSEP) Research fellowship" 2015. 2 años Investigador responsable
-Synaptic Control Of Ng2 Cell Fate During Myelination And Myelin Repair In White Matter "Medical Research Foundation (FRM, France) Research fellowship" 2013 3 años Investigador responsible.
-De la Paz JF, Zambrano NO, Ortiz FC, Llanos-Rivera A. 2023 A New Bioassay for the Detection of Paralytic and Amnesic Biotoxins Based on Motor Behavior Impairments of Zebrafish Larvae International Journal of Molecular Sciences. 1422-0067 doi: 10.3390/ijms24087466
-Allendes FJ, Díaz HS, Ortiz FC, Marcus NJ, Quintanilla R, Inestrosa NC, Del Rio R. 2023 Cardiovascular and autonomic dysfunction in long-COVID syndrome and the potential role of non-invasive therapeutic strategies on cardiovascular outcomes Frontiers in Medicine. 2296-858X doi: 10.3389/fmed.2022.1095249
-Maldonado PP, Guevara C, Olesen MA, Orellana JA, Quintanilla RA, Ortiz FC. 2022 Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways Antioxidants. 2076-3921 doi: 10.3390/antiox11061146
-Toledo C, Andrade DC, Diaz-Jara E, Ortolani D, Bernal-Santander I, Schwarz KG, Ortiz FC, Marcus NJ, Oliveira LM, Takakura AC, Moreira TS, Del Rio R. 2022 Cardiorespiratory alterations following intermittent photostimulation of RVLM C1 neurons: Implications for long-term blood pressure, breathing and sleep regulation in freely moving rats Acta Physiologica. 1748-1716. https://doi.org/10.1111/apha.13864
-Díaz HS, Ríos-Gallardo A, Ortolani D, Díaz-Jara E, Flores MJ, Vera I, Monasterio A, Ortiz FC, Brossard N, Osorio 2022 Lipid-Encapsuled Grape Tannins Prevent Oxidative-Stress-Induced Neuronal Cell Death, Intracellular ROS Accumulation and Inflammation Antioxidants. 2076-3921 doi: 10.3390/antiox11101928
-Olivares MJ, Toledo C, Ortolani D, Ortiz FC, Díaz HS, Iturriaga R, Del Río R. 2022. Sleep dysregulation in sympathetic-mediated diseases: implications for disease progression Sleep. 0161-8105 doi: 10.1093/sleep/zsac166
-Toledo C, Ortolani D, Ortiz FC, Marcus NJ, Del Rio R . 2022. Potential Role of the Retrotrapezoid Nucleus in Mediating Cardio-Respiratory Dysfunction in Heart Failure With Preserved Ejection Fraction Frontiers in Physiology. 1664-042X doi: 10.3389/fphys.2022.863963
-Schwarz KG, Pereyra KV, Toledo C, Andrade DC, Díaz HS, Díaz-Jara E, Ortolani D, Rios-Gallardo A, Arias P, Las Heras A, Vera I, Ortiz FC, Inestrosa NC, Vio CP, Del Rio R. 2021. Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non ischemic chronic heart failure Biological Research. 0717-6287 doi: 10.1186/s40659-021-00365-z
-Guevara C, Ortiz FC. 2021 Glial-derived transforming growth factor β1 (TGF-β1): a key factor in multiple sclerosis neuroinflammation Neural Regeneration Research, 1876-7958 doi: 10.4103/1673-5374.293147
-Andrade DC, Melipillan C, Toledo C, Rios-Gallardo A, Marcus NJ, Ortiz FC, Martinez G, Muñoz Venturelli P, Del Rio R. 2021 Heart rate and cardiac autonomic responses to concomitant deep breathing, hand grip exercise, and circulatory occlusion in healthy young adult men and women Biological Research. 0717-6287 doi: 10.1186/s40659-021-00355-1.
-Díaz-Jara E, Díaz HS, Rios-Gallardo A, Ortolani D, Andrade DC, Toledo C, Pereyra KV, Schwarz K, Ramirez G, Ortiz FC, Andía ME, Del Rio R, 2021, Exercise training reduces brainstem oxidative stress and restores normal breathing function in heart failure Free Radical Biology Medicine, 0891-5849 doi: 10.1016/j.freeradbiomed.2021.06.032.
-Andrade DC, Díaz-Jara E, Toledo C, Schwarz KG, Pereyra KV, Díaz HS, Marcus NJ, Ortiz FC, Ríos-Gallardo AP, Ortolani D, Del Rio R, 2021, Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive Scientific Reports, 2045-2322 doi: 10.1038/s41598-021-93791-8
-Pereyra K, Schwarz K, Andrade D, Toledo C, Rios-Gallardo A, Díaz-Jara E, Bastías S, Ortiz FC, Ortolani D, Del Rio R,. 2021, Paraquat herbicide diminishes chemoreflex sensitivity, induces cardiac autonomic imbalance and impair cardiac function in rats American Journal of Physiology Heart and Circulatory Physiology, 0363-6135 doi: 10.1152/ajpheart.00710.2020
-Varas R, Ortiz FC, 2020 Neuroinflammation in demyelinating diseases: oxidative stress as a modulator of glial cross-talk Current Pharmaceutical Design, 1873-4286 https://doi.org/10.2174/1381612825666191216125725
-Sáez JC, Vargas AA, Hernández DE, Ortiz FC, Giaume C, Orellana JA, 2020 Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species International Journal of Molecular Sciences, 1422-0067. doi: 10.3390/ijms21113970.
-Ortiz FC, Puebla C, 2020 Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression Neural Regeneration Research, 1876-7958. doi: 10.4103/1673-5374.264450
-Ortiz FC, Habermacher C, Graciarena M, Houry P-Y, Nishiyama A, Nait-Oumesmar B, Angulo MC, 2019 Neuronal activity in vivo enhances functional myelin repair JCI insight, 2379-3708 doi: 10.1172/jci.insight.123434
-Vejar S, Oyarzún JE, Retamal MA, Ortiz FC, Orellana JA, 2019, Connexin and pannexin-based channels in oligodendrocytes: implications in brain health and disease Frontiers in Cellular Neuroscience, 1662-5102 doi: 10.3389/fncel.2019.00003
-"Baraban M, Retamal MA, Ortiz FC" 2019 Editorial: Physiology of Myelin Forming Cells, From Myelination to Neural Modulators. Frontiers in Cellular Neuroscience, 1662-5102, doi: 10.3389/fncel.2019.00475