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Dr. Luis Constandil

E-mail: 
luis.constandil@usach.cl
Biografía: 

Doctor en Ciencias Biológicas, P. Universidad Católica de Chile, 1997.

Biólogo, P. Universidad Católica de Chile, 1990

Lineas de Investigación: 

Biomedicina

Proyectos: 

-Role of DNIC in a rat model of fibromyalgia induced by neonatal stress: neurotransmitters and glial modulation in the SRD and epigenetic influences                 FONDECYT 1231042, 2023-2027, Investigador Responsable

-Role of DNIC in a rat model of fibromyalgia induced by neonatal stress: neurotransmitters and glial modulation in the SRD and epigenetic influences                 Dicyt 5392202CC-AC, 2022, Investigador Responsable

-Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the mechanisms of chronic pain. FONDECYT 1181622, 2018-2021, Investigador Responsable

-Estudio Preclínico del rol de la pannexina 1 (Panx1) en los circuitos espinales del dolor, DYCIT 021543CC, 2015-2016. Investigador Responsable

-Nanopartículas con polímero biodegradable y biocompatible PLGA cargadas con el fármaco de uso humano pentoxifilina para el tratamiento del dolor crónico              CORFO IDL3-25698, 2014-2015. Investigador Responsable

-Role of spinal cord ltp in the triggering and maintenance of chronic pain: a long-lasting study in the rat FONDECYT 1120952, 2012-2014. Investigador Responsable

-Centro de desarrollo en Nanociencia y Tecnología. CONICYT- Programa de financiamiento Basal para Centros científicos y tecnológicos de excelencia                BASAL Nº FB0807 Renovación, 2020 Investigador Asociado

Últimas Publicaciones: 

-Lobos, N., Lux, S., Zepeda, R. J., Pelissier, T., Marcos, J. L., Bustos-Quevedo, G., Hernández, A., & Constandil, L. ,2023, Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice. International Journal of Molecular Sciences 1661-6596 doi: 10.3390/ijms24098359

-Cayupe, B., Troncoso, B., Morgan, C., Sáez-Briones, P., Sotomayor-Zárate, R., Constandil, L., Hernández, A., Morselli, E., & Barra, R., 2022, The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition.    International Journal of Molecular Sciences, 1661-6596, doi: 10.3390/ijms231911965

-Morgan, C., Sáez-Briones, P., Barra, R., Reyes, A., Zepeda-Morales, K., Constandil, L., Ríos, M., Ramírez, P., Burgos, H., & Hernández, A., 2022, Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity.                  International Journal of Molecular Sciences, 1661-6596, doi: 10.3390/ijms231710089

-Bravo, D., Zepeda-Morales, K., Maturana, C. J., Retamal, J. S., Hernández, A., Pelissier, T., Barra, R., Sáez-Briones, P., Burgos, H., & Constandil, L. (2022), 2022, NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats.          International Journal of Molecular Sciences, 1661-6596, doi: 10.3390/ijms23126705

-Casadei, M., Fiore, E., Rubione, J., Domínguez, L. M., Coronel, M. F., Leiguarda, C., García, M., Mazzolini, G., Villar, M. J., Montaner, A., Constandil, L., Romero-Sandoval, E. A., & Brumovsky, P. R. , 2022, IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve                 Pain, 0304-3959   doi: 10.1097/j.pain.0000000000002476

-Cayupe, B., Morgan, C., Puentes, G., Valladares, L., Burgos, H., Castillo, A., Hernández, A., Constandil, L., Ríos, M., Sáez-Briones, P., & Barra, R. , 2021, Hypertension in Prenatally Undernourished Young-Adult Rats Is Maintained by Tonic Reciprocal Paraventricular-Coerulear Excitatory Interactions         Molecules 1420-3049, doi: 10.3390/molecules26123568

-Leiguarda, C., Villarreal, A., Potilinski, C., Pelissier, T., Coronel, M. F., Bayo, J., Ramos, A. J., Montaner, A., Villar, M. J., Constandil, L., & Brumovsky, P. R. , 2021, Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization     Journal of Neuroimmune Pharmacology, 1557-1890, doi: 10.1007/s11481-021-09983-6

-Cerro, D., Bustos, G., Villegas, C., Buendia, N., Truffa, G., Godoy, M. P., Rodríguez, F., Rojas, A., Galotto, M. J., Constandil, L., Yáñez-S, M., Romero, J., & Torres, A.,  2021, Effect of supercritical incorporation of cinnamaldehyde on physical-chemical properties, disintegration and toxicity studies of PLA/lignin nanocomposites    International Journal of Biological Macromolecules                 , 0141-8130, doi: 10.1016/j.ijbiomac.2020.11.140

-Leiguarda, C., Potilinski, C., Rubione, J., Tate, P., Villar, M. J., Montaner, A., Bisagno, V., Constandil, L., 2021, IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model Journal of Neuroimmune Pharmacology, 1557-1890. doi: 10.1007/s11481-020-09971-2

-Valeria González, Teresa Pelissier, Victoria Cazanga1 Alejandro Hernández and Luis Constandil., 2021 Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic           Frontiers in Pharmacology, 1663-9812. doi: 10.3389/fphar.2020.00566

-Paulina D. Ramírez-García, Jeffri S. Retamal, Priyank Shenoy, Wendy Imlach, Matthew Sykes, Nghia Truong, Luis Constandil, Teresa Pelissier, Cameron J. Nowell1, Song Y. Khor1, Louis M. Layani1, Chris Lumb1, Daniel P. Poole1, TinaMarie Lieu, Gregory D. Stewart, Quynh N. Mai, Dane D. Jensen, Rocco Latorre, Nicole N. Scheff, Brian L. Schmidt, John F. Quinn1, Michael R. Whittaker, Nicholas A. Veldhuis, Thomas P. Davis, Nigel W. Bunnett., 2019. A pH-Responsive Nanoparticle Targets the Neurokinin 1 Receptor in Endosomes to Prevent Chronic Pain Nature Nanotechnology. 1748-3387. doi: 10.1038/s41565-019-0568-x

-Burgos H, Hernández A, Constandil L, Ríos M, Flores O, Puentes G, Hernández K, Morgan C, Valladares L, Castillo A, Cofre C, Milla LA, Sáez-Briones P, Barra R., 2019, Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats         Behavioural Brain Research, 0166-4328. doi: 10.1016/j.bbr.2019.02.001

-Lux S, Lobos N, Lespay-Rebolledo C, Salas-Huenuleo E, Kogan MJ, Flores C, Pinto M, Hernandez A, Pelissier T, Constandil L.  2019, The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat     Jounal of Pharmacy and Pharmacology, 0022-3573    doi: 10.1111/jphp.13064